Chemical constituents from Cordia myxa L. (Boraginaceae) and their antibacterial activity

Abstract

Chemical investigation of Cordia myxa L. (Boraginaceae) resulted in the isolation of the following ten known compounds: 1-naphthaleneacetic-5-carboxy-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a-trimethyl-[1S-(1α,2β, 4a,8aα)]-acid (1), hexacosanoate-1-glyceryl (2), 3β-urs-12,20(30)-diene-27,28-dioic acid (3), 3β-D-glucopyranosylurs-12,20(30)-diene-27,28-dioic acid (4), stigmasterol (5), stigmasterol-3-O-β-D-glucopyranoside (6), oleanolic-acid (7), 3-O-acetyl-oleanolic acid (8), betulin (9) and spinasterol-3β-O-D-glucopyranoside (10). The isolated compounds were characterised by using spectroscopic methods, 1D and 2D NMR, mass spectroscopy (ESI-MS) and by comparison with the literature data. To the best of our knowledge, compounds 1, 3, 4, 8 and 10 were isolated for the first time from the Cordia genus. This result improves the chemotaxonomy knowledge of the Cordia genus. The antibacterial activities were performed by the Muller–Hinton agar diffusion method. The antibacterial activities were studied on Salmonella typhi, Staphylococcus aureus, Vibrio cholerae, Pseudomonas aeruginosa and Escherichia coli ATCC 25922. Compounds 8 and 9, at 20.0 mg/mL resulted to be effective antimicrobial against E. coli, V. cholerae and P. aeruginosa.