Chemical Constituents, Bioactivities, and Pharmacological Mechanisms of Dendrobium officinale: A Review of the Past Decade.

Abstract

Dendrobium officinale, a plant in the Orchidaceae family, has been used in traditional Chinese medicine for thousands of years. Sweet and slightly cold in nature, it can invigorate the stomach, promote fluid production, nourish Yin, and dissipate heat. Over the past decade, more than 60 compounds have been derived from D. officinale, including flavonoids, bibenzyl, and phenanthrene. Various studies have explored the underlying pharmacological mechanisms of these compounds, which have shown antitumor, hypoglycemic, hypertensive, gastrointestinal-regulatory, visceral organ protection, antiaging, and neurorestorative effects. This paper presents a systematic review of the structural classification, biological activity, and pharmacological mechanisms of different chemical components obtained from D. officinale over the past decade. This review aims to provide a reference for future study and establish a foundation for clinical applications. Furthermore, this review identifies potential shortcomings in current research as well as potential directions and methodologies in future plant research.