Abstract
Salacia chinensis L., known as “Chop mao” in Vietnam, is a climbing shrub that belongs to the Celastraceae family. The stem of S. chinensis L. is used as a traditional medicine for the treatment of diabetes, rheumatoid arthritis, back pain, … The dried powdered stem of S. chinensis L. was collected in Phu Yen province and was extracted with methanol to yield methanol extract. The methanol extract was suspended in H2O and partitioned successively with n-hexane, CHCl3, EtOAc to obtain n-hexane, CHCl3, EtOAc, and H2O fractions, respectively. The CHCl3 fraction was subjected to a series of chromatographic separation to afford four purified compounds including 3-oxolup-20(29)-en-30-al (1), betulin-3-caffeate (2), 2-(4-hydroxy-3,5-dimethoxylphenyl)ethanol (3), and acetosyringone (4). Their structures were elucidated on the basis of the spectroscopic analysis and comparison with literature data. The isolated compounds were tested for their α-glucosidase inhibitory activity. The result indicated that all compounds (1-4) possessed significant α-glucosidase at the testing concentration of 100 µM with the percent inhibition values of 9.5 ± 1.3, 70.89 ± 0.25, 44.2 ± 1.6, and 6.7 ± 1.7 %, respectively. In addition, betulin-3-caffeate (2) and 2-(4-hydroxy-3,5-dimethoxylphenyl)ethanol (3) show more potent α-glucosidase inhibitory activity, with IC50 values of 69.7 and 152.0 µM, respectively, than that of positive control acarbose (IC50 = 214.5 µM).
Highlights
a climbing shrub belonging to the Celastraceae family
The stem of S. chinensis L. is used as a traditional medicine to treat of diabetes
The dried powdered stem of S. chinensis L. was collected in Phu Yen province
Summary
Thành phần hóa học và hoạt tính ức chế enzyme α-glucosidase của thân cây Chóp mao ( Salacia chinensis L.). Dương Thị Thanh Trúc[1], Đặng Hoàng Phú[1], Lê Hữu Thọ1,*, Đỗ Văn Nhật Trường[1], Nguyễn Xuân Hải[1], Nguyễn Minh Hoàng[2], Nguyễn Thị Thanh Mai[1], Nguyễn Trung Nhân[1]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Science and Technology Development Journal - Natural Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.