Chemical Compositions, Mosquito Larvicidal and Antimicrobial Activities of Essential Oils from Five Species of Cinnamomum Growing Wild in North Central Vietnam

Do N Dai,Nguyen T Yen,Dao T.M Chau,William N Setzer,Le T Huong,Nguyen H Hung,Nguyen T Chung

doi:10.3390/molecules25061303

Do N Dai, Nguyen T Yen + Show 5 more

Open Access

https://doi.org/10.3390/molecules25061303

Copy DOI

Abstract

Members of the genus Cinnamomum (Lauraceae) have aromatic volatiles in their leaves and bark and some species are commercially important herbs and spices. In this work, the essential oils from five species of Cinnamomum (C. damhaensis, C. longipetiolatum, C. ovatum, C. polyadelphum and C. tonkinense) growing wild in north central Vietnam were obtained by hydrodistillation, analyzed by gas chromatography and screened for antimicrobial and mosquito larvicidal activity. The leaf essential oil of C. tonkinense, rich in β-phellandrene (23.1%) and linalool (32.2%), showed excellent antimicrobial activity (MIC of 32 μg/mL against Enterococcus faecalis and Candida albicans) and larvicidal activity (24 h LC50 of 17.4 μg/mL on Aedes aegypti and 14.1 μg/mL against Culex quinquefasciatus). Cinnamomum polyadelphum leaf essential oil also showed notable antimicrobial activity against Gram-positive bacteria and mosquito larvicidal activity, attributable to relatively high concentrations of neral (11.7%) and geranial (16.6%). Thus, members of the genus Cinnamomum from Vietnam have shown promise as antimicrobial agents and as potential vector control agents for mosquitoes.

Highlights

The Lauraceae is a large family of tropical and subtropical trees and shrubs [1]
Plant materials were collected from mature Cinnamomum trees from different locations in north central Vietnam
The essential oils were analyzed by gas-chromatography–mass spectrometry (GC-MS) and gas chromatography–flame ionization detector (GC–FID)

Summary

Introduction

The Lauraceae is a large family of tropical and subtropical trees and shrubs [1]. In this family, the genus Cinnamomum is comprised of around 250 species with concentrations in east and southeastAsia [1]. The Lauraceae is a large family of tropical and subtropical trees and shrubs [1]. In this family, the genus Cinnamomum is comprised of around 250 species with concentrations in east and southeast. Vietnam is home to 45 species of Cinnamomum [2,3], many of which are used in traditional medicine, for essential oils, as well as for timber [4,5]. We are in the midst of a post-antibiotic era. Numerous pathogenic microorganisms have developed resistance to commonly used antibiotic agents [6,7]. Klebsiella pneumoniae [8], Pseudomonas aeruginosa [9] and Staphylococcus aureus [10], three organisms that are major causes of nosocomial

Methods

Discussion

Conclusion