Abstract
Graphical Mastic gum is derived from the tree named Pistacia lentiscus that is grown only in Island Hios of Greek. Since Mastic was first reported to kill Helicobacter pylori (H. pylori) in 1998, there has been no further study to elucidate which component of mastic specifically shows the antimicrobial activity against H. pylori. In this study, we examined which component of mastic gum was responsible for anti-H. pylori activity. We prepared the essential oil of mastic gum and identified 20 constituents by GC–MS analysis. Ten standard components were assayed for anti-H. pylori activity, and it clarified that α-terpineol and (E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer. These components could be useful to overcome the drug-resistance H. pylori growth in stomach.
Highlights
Helicobacter pylori (H. pylori), gram-negative bacterium, induces chronic gastric infection of one-half of the world population
Ten standard components were assayed for anti-H. pylori activity, and it clarified that a-terpineol and (E)-methyl isoeugenol showed the anti-H. pylori activity against four different H. pylori strains that were established from patients with gastritis, gastric ulcer and gastric cancer
We examined which component of the essential oil prepared from mastic gum could inhibit the growth of H. pylori
Summary
Helicobacter pylori (H. pylori), gram-negative bacterium, induces chronic gastric infection of one-half of the world population. Infection with H. pylori is often associated with a viable proportion of duodenal ulcer, gastric ulcer, and gastric carcinoma [1, 2]. During chronic infection process of H. pylori for decades, the bacterium infection initially induces chronic gastritis, and progresses to atrophic. Mallotus philippinenesis that are effective against clarithromycin-and metronidazole-resistant strains of Japanese and Pakistani H. pylori. Mastic gum, which is a resin secreted from the stem of Pistacia lentiscus, was found to be effective against H. pylori [8]. We examined which component of the essential oil prepared from mastic gum could inhibit the growth of H. pylori. The bactericidal activity of the mastic components will be discussed in association with their drug resistance reversal effects
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