Abstract
OBJECTIVE:The present study aimed to evaluate the sedative and anxiolytic effects of the essential oils and hydroalcoholic extract of Kelussia odoratissima Mozaff. (K. odoratissima) in mice by utilizing an elevated plus maze. The chemical composition of its essential oil was also determined.METHODS:The hydroalcoholic extract or essential oil fraction from this plant were administered intraperitoneally to male mice at various doses 30 min before testing. The anxiolytic and sedative effects were determined by an elevated plus maze and locomotor activity tests, respectively.RESULTS:According to the results, none of the administered doses of hydroalcoholic extract or essential oil fraction of K. odoratissima changed the percentage of the time spent or number of entries into the open arms of the elevated plus maze. In contrast, the cumulative spontaneous locomotor activity of mice treated with the essential oil or hydroalcoholic extract was significantly decreased. Chemical analysis of the essential oil by Gas chromatography-mass spectromentry (GC-MS) showed that 3-butylidene-4,5-dihydrophthalide (85.9%) was the major component.CONCLUSION:These data confirm the sedative properties of K. odoratissima, yet there were no profound anxiolytic effects observed.
Highlights
Anxiety disorders are among the most varied mental disorders, and they normally have a considerable impact on quality of life
According to the results, none of the administered doses of hydroalcoholic extract or essential oil fraction of K. odoratissima changed the percentage of the time spent or number of entries into the open arms of the elevated plus maze
The cumulative spontaneous locomotor activity of mice treated with the essential oil or hydroalcoholic extract was significantly decreased
Summary
Anxiety disorders are among the most varied mental disorders, and they normally have a considerable impact on quality of life. Substantial and prolonged stress and anxiety can adversely affect immune function, hormone levels, enzymes and gastrointestinal function. With a worldwide occurrence of 16.6%, anxiety disorders are among the most common mental disorders and a major cause of disability.[1] A wide range of medications are available for the treatment of stress and anxiety-related conditions; none of these therapies are completely safe and without adverse effects. Interventions for stress and anxiety range from nutritional support to the use of medications such as benzodiazepines, antidepressants, b-blockers and antipsychotics.[2].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
