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Abstract
In the current study, the chemical constituents of leaf essential oil from Cananga odorata (Lam.) Hook. F. & Thomson were identified by GC/MS analysis. A total of 25 components (91.1 %) in the essential oil were identified. The major compounds present in the oil were trans-caryophyllene (19.7 %), ocimene (13.2 %), E, E-α-farnesene (10.3 %), phenylmethyl ester (5.6 %), farnesyl acetone (5.1 %), t-muurolol (4.2 %), farnesol (3.7 %), β-elemene (3.1 %), α-cadinol (3.0 %), copaene (2.9 %), benzyl benzoate (2.3 %), trans-farnesol (2.1 %). The essential oil is rich in sesquiterpenoids including sesquiterpenes hydrocarbon (42.3 %), monoterpene hydrocarbons (18.1 %), and in addition to that oxygenated compound representing (30.7 %). The Antioxidant efficiency of essential oil of C. odorata leaves was performed by DPPH radical method together with BHA as standard. The essential oil showed concentration-dependent antiradical activity with EC50 value of 19.5±1.25 μg/mL, when compared with standard BHA which showed EC50 value of 1.10±0.55 μg/mL. The in vitro anticancer potential of essential oil was evaluated by using MOLT-3 cell line by MTT assay. The C. odorata essential oil exhibited significant anticancer activity with IC50 value of 44.22 μg/mL. From the results, C. odorata essential oil has significant antioxidant and anticancer properties which can be utilised as a natural supplement as antioxidant and anticancer agents in pharmaceutical and food industries since it is available throughout the year.
Published Version
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