Abstract
This work is devoted to the study of the chemical composition and the evaluation of the biological activities of essential oils (EOs) extracted from the flowers of Asteriscus graveolens Forssk. plant. The EO sample was obtained by hydrodistillation and the chemical composition analysis was performed using GC and GC/MS. The major chemical components characterizing the EO were cis-chrysanthenyl acetate (44.30%) and cis-8-acetoxychrysanthenyl acetate (33.70%). Antioxidant activity was determined using DPPH and Phosphomolybdenum tests. Although the EO presented a weak scavenging activity (420.16 mg/mL), it exhibited good reducing power using the Phosphomolybdenum assay (0.28 AAEC/mg). The most important antibacterial activity was noted for Bacillus cereus. The oil revealed a remarkable activity against the nine fungi species tested with percentage inhibition up to 94.12% for Fusarium culmorum (BTCR). More important, this work investigated for the first time the anticancer effect of this EO on two types of cancer cell lines (human liver carcinoma and Rat pheochromocytoma cell lines). The EO showed a high anticancer activity against both tumor cell lines comparing to the positive control.
Highlights
The biological properties of natural products as essential oils (EOs) are studied to search a new drugs, antibiotics and pesticides (Buchanan et al 2000)
Many works were devoted for the study of biological properties of EOs, the antimicrobial activity of oils extracted from thyme; rosemary and chamomile were demonstrated (Bakkali et al 2008; Dorman and Deans 2000; Floris et al 1996; Marino et al 2001)
We report the results of a study aimed to define chemical composition and to evaluate antioxidant, antibacterial, antifungal and for the first time the anticancer activity of A. graveolens EO
Summary
The biological properties of natural products as essential oils (EOs) are studied to search a new drugs, antibiotics and pesticides (Buchanan et al 2000). They have been screened for their potential uses as alternative remedies for the treatment. It’s very common in the North Africa Their leaves are collected in the spring, they are prepared as infusion or decoction; the sap of the fresh leaves is used as drops for the nose and poultice for headaches. We report the results of a study aimed to define chemical composition and to evaluate antioxidant, antibacterial, antifungal and for the first time the anticancer activity of A. graveolens EO
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