Abstract
As a classical herb pair in clinics of traditional Chinese medicine, Curcumae Rhizoma–Sparganii Rhizoma (HP CR–SR) is used for activating blood circulation to remove blood stasis. The essential components in HP CR–SR and its single herbs were comparatively analyzed using gas chromatography-mass spectrometry data. 66, 22, and 54 components in volatile oils of Curcumae Rhizoma, Sparganii Rhizoma, and HP CR–SR were identified, and total contents accounted for 75.416%, 91.857%, and 79.553% respectively. The thirty-eight components were found in HP CR–SR, and not detected in single herbs Curcumae Rhizoma and Sparganii Rhizoma. The highest radical trapping action was seen by an essential oil of HP CR–SR (IC50 = 0.59 ± 0.04 mg/mL). Furthermore, the HP CR–SR essential oil showed more remarkable cytotoxicity on tumor cell lines than that of the single herbs Curcumae Rhizoma and Sparganii Rhizoma in a dose-dependent manner: IC50 values showing 32.32 ± 5.31 μg/mL (HeLa), 34.76 ± 1.82 μg/mL (BGC823), 74.84 ± 1.66 μg/mL (MCF-7), 66.12 ± 11.23 μg/mL (SKOV3), and 708.24 ± 943.91 μg/mL (A549), respectively. In summary, the essential oil of HP CR–SR is different from any one of Curcumae Rhizoma and Sparganii Rhizoma, nor simply their superposition, and HP CR–SR oil presented more remarkable anticancer and antioxidant activities compared with Curcumae Rhizoma and Sparganii Rhizoma oils.
Highlights
Herbal pair (HP), as a basic unit in compatibility of traditional Chinese medicine (TCM), has been widely applied in folk medicine for thousands of years [1,2]
The difference between HP oil and CR oil has been analyzed by gas chromatography-mass spectrometry (GC-MS)
The essential oils of CR, SR, and HP Curcumae Rhizoma–Sparganii Rhizoma (CR–SR) were extracted by hydrodistillation, and the yield was
Summary
Herbal pair (HP), as a basic unit in compatibility of traditional Chinese medicine (TCM), has been widely applied in folk medicine for thousands of years [1,2]. Based on the compatibility mechanism, HP was composed of two relatively fixed herbs in the clinic. When the two fixed herbs are used together, interactions will occur so as to enhance the effect, reduce the toxicity or even remove the side effects compared with using a single herb alone [3,4,5]. Compared with TCM compatibility, HP is based on the basic features and principles of TCM compatibility, and easier to study due to their simpler chemical compositions [2].
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