Abstract
Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol (Ba-W/Ba-C) were prepared to evaluate their antioxidant and antitumor activities. Both PFEE-W and PFEE-C show the antioxidant activity and PFEE-W is stronger than PFEE-C. The antioxidant activities of their subfractions are in the following order: Ea > Ba > Pe. Moreover, PFEE-W and PFEE-C significantly inhibit the proliferation of murine melanoma B16 cells, human esophageal cancer Eca-109 cells, human gastric cancer BGC823 cells and human cervical cancer HeLa cells through induction of apoptosis, which partially mediated by reactive oxygen species. The antitumor activities of their subfractions are in the following order: Ea ≥ Pe > Ba. Pe-W shows higher antitumor activity compared with Pe-C, which might be correlated with the difference of their components identified by gas chromatography-mass spectrometry. These results suggest that both wild and cultivated P. ferulae have antioxidant and antitumor activities, and cultivated P. ferulae could be used to replace wild one in some functions.
Highlights
Cancer is the second leading cause of death in the world
A growing body of research including ours has reported that P. ferulae extracts and some components show antioxidant, antihyperlipidemic, antitumor, antimicrobial and immunoregulatory effects (Alam et al, 2012; Choi et al, 2004; Kalyoncu et al, 2010; Li et al, 2015a; Wang et al, 2014)
PFEE-W exhibited higher antitumor activity than PFEE-C, both PFEE-C and PFEE-W significantly inhibited the growth of hepatocellular carcinoma cells through induction of apoptosis (Yang et al, 2018)
Summary
Cancer is the second leading cause of death in the world. In 2015, there were 17.5 million cancer cases and 8.7 million deaths globally, which included around 4.3 million cancer cases and 2.8 million deaths in China (Chen et al, 2016; Global Burden of Disease Cancer Collaboration et al, 2017). Antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts. A growing body of research including ours has reported that P. ferulae extracts and some components show antioxidant, antihyperlipidemic, antitumor, antimicrobial and immunoregulatory effects (Alam et al, 2012; Choi et al, 2004; Kalyoncu et al, 2010; Li et al, 2015a; Wang et al, 2014). Alam et al (2012) have shown that the acetonic and methanolic extracts of P. ferulae exhibit better antioxidant activities than hot water extracts. We compared the antitumor activities of wild and cultivated P. ferulae ethanol extracts (PFEE-W and PFEE-C). Further investigation is needed to determine whether wild and cultivated P. ferulae have similar or different antioxidant activities and antitumor effects on different types of tumors
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