Abstract
The Myric rubra leaves essential oil (MEO) was extracted by steam distillation and its major component was analyzed by gas chromatography mass spectrum (GC-MS). The result showed that 20 kinds of essential oils were identified. with humulene (26.03%), caryophyllene (19.74%), ledene oxide-(II) (16.37%) and γ-himachalene (7.7%) being the major constituents. The antioxidant activity of MEO were analyzed by 2,2-diphenyl-1-picrylhydrazylassay (DPPH) and oxygen radical absorbance capacity (ORAC) assay respectively, Analogues of vitamin E (Trolox) was positive control. The results showed that the IC50 of DPPH radical scavenging is 0.0576 mg/mL and the ORAC value of fluorescence spectrometry is 1.32mmol TE/g. The anticancer effect of obtained MEO was tested in A549 lung cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. MEO IC50 value of 163 μg/mL was obtained with significantly inhibited cell proliferation in concentration-dependant manner. MEO could be useful for pharmaceutical, food and cosmetic industry, because of its strong antioxidant and anticancer activity.
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