Abstract
Phytochemical and bioactivity analyses of pistachio hulls revealed the presence of anacardic acids (3198mg/100g), fatty acids (1500mg/100g), and phytosterols (192mg/100g) as major components. Carotenoids (4.93mg/100g), chlorophylls (10.27mg/100g), tocopherols (8.83mg/100g), and three triterpene acids (mangiferolic, isomangiferolic and mangiferonic acids) were characterized. A polar (P) extract contained quercetin-3-O-glucoside (6.27mg/g), together with smaller concentrations of quercetin, myricetin and luteolin flavonoids, accounting for 5.53mg/g. Gallotannins and other phenolic compounds esterified with a gallic acid moiety characterized the P extract. P extract potently inhibited the release of nitric oxide (NO) and reactive oxygen species (ROS) in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. The mRNA expression levels of the anti-inflammatory cytokine COX-2 were significantly inhibited by fractions P2-P5, while IL-6 was only inhibited by fraction P3. Moreover, the P extract significantly decreased the non-mitochondrial oxidative burst associated with inflammatory response in macrophages.
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