Abstract
The chemical composition of the essential oil obtained by hydrodistillation from aerial parts of A. leucotrichus Cosson & Durieu (Apiaceae) grown in the south of Algeria (El-Oued) was determined by GC-MS analysis. The oil was found to be rich in perilladehyde 64.66% and D-Limonene 26.99%. The biological activity of A. leucotrichus Cosson & Durieu essential oil has been investigated. The in vitro antimicrobial activity of the essential oil sample was tested on eight strains, one yeast and one fungi. The test showed interesting antimicrobial properties, especially on Salmonella enterica and E. coli, the antioxidant capacity of the oil was measured using the cyclic voltammetry, and the AAT value of A. leucotrichus essential oil was evaluated 47.84 mg α-TE/L. In addition, the antitumor activity showed that the oil of A. leucotrichus was very significant against the HCT116 colon cancer cell line. KEY WORDS: Ammodaucus leucotrichus, Antioxidant activity, Anticancer activity, Cyclic voltammetry Bull. Chem. Soc. Ethiop. 2019, 33(3), 541-549. DOI: https://dx.doi.org/10.4314/bcse.v33i3.14
Highlights
Ammodaucus leucotrichus Cosson & Durieu belonging to Apiaceae family, is one of the huge plant's diversity of the Sahara desert [1]
The leaves are used to aromatize tea. It is much-appreciated as a spice food in the El-Oued area [8]. This plant is known to grow wild in Algeria and in spite of its wide uses in traditional medicine, a full investigation of the chemical composition of the essential oil extracted from the aerial parts, has never been mentioned before
This study is considered as the first original report giving full details of the composition as well as the antimicrobial, anticancer and antioxidant properties using spectrophotometrical (DPPH) and electrochemical methods of the aerial parts oil obtained from Ammodaucus leucotrichus Coss & Dur, to effectively exploit of the usage of this plant
Summary
Ammodaucus leucotrichus Cosson & Durieu belonging to Apiaceae family, is one of the huge plant's diversity of the Sahara desert [1]. This study is considered as the first original report giving full details of the composition as well as the antimicrobial, anticancer and antioxidant properties using spectrophotometrical (DPPH) and electrochemical methods (cyclic voltammetry) of the aerial parts oil obtained from Ammodaucus leucotrichus Coss & Dur, to effectively exploit of the usage of this plant. The essential oil was evaluated for its anticancer activity against HePG2 (Hepatic) and HCT116 (Colon) human cancerous cell lines.
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