Abstract
Seaweed has tremendous potentials as an alternative source of high-quality food products that have attracted research in recent times, due to their abundance and diversity. In the present study, three selected seaweed species commonly found in the Malaysian Peninsular, Ulva intestinalis, Halimeda macroloba, and Sargassum ilicifolium, were subjected to preliminary chemical screening and evaluated for α-glucosidase inhibitory and cytotoxic activities against five cancer cell lines. Chemical composition of U. intestinalis, H. macroloba, and S. ilicifolium methanolic extracts was evaluated by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Our results revealed the highest total carotenoids (162.00 μg g−1 DW), chlorophyll a (313.09 ± 2.53 μg g−1 DW), and chlorophyll b (292.52 ± 8.84 μg g−1 DW) concentrations in U. intestinalis. In the α-glucosidase inhibitory activity, S. ilicifolium demonstrated the lowest efficacy with an IC50 value of 38.491 ppm compared to other species of seaweed. H. macroloba extract, on the other hand, was found to be the most cytotoxic toward MCF-7 and HT 29 cells with IC50 of 37.25 ± 0.58 and 21.32 ± 0.25 μg/mL, respectively, compared to other cell lines evaluated. Furthermore, H. macroloba extract was also found to be less toxic to normal cell (3T3) with IC50 of 48.80 ± 0.11 μg/mL. U. intestinalis extract exhibited the highest cytotoxicity toward Hep G2 cells with IC50 of 23.21 ± 0.11 μg/mL, whereas S. ilicifolium was less toxic to MDA- MB231 cell with IC50 of 25.23 ± 0.11 μg/mL. Subsequently, the GC-MS analysis of the methanolic extracts of these seaweed samples led to the identification of 27 metabolites in U. intestinalis, 22 metabolites in H. macroloba, and 24 metabolites in S. ilicifolium. Taken together, the results of this present study indicated that all the seaweed species evaluated are good seaweed candidates that exhibit potential for cultivation as functional food sources for human consumption and need to be promoted.
Highlights
Marine seaweed is a diverse group of marine resources that are commonly found in the maritime regions of the world.Seaweed epitomizes a lavish cradle of natural products, containing highly treasured chemicals that have not been properly investigated for their valuable compositions
The results of this present study indicated that all the seaweed species evaluated are good seaweed candidates that exhibit potential for cultivation as functional food sources for human consumption and need to be promoted
The objectives of the present study were to evaluate the chemical compositions and investigate the α-glucosidase inhibitory and cytotoxic activities of extracts of 3 selected species of seaweed available in Peninsular Malaysia against five cancer cell lines including MCF-7 cells, MDA-MB-231 cells, HT-29 cells, Hep G2 cells, and 3T3 cells using a colorimetric (MTT) assay. e three selected species of seaweed investigated include U. intestinalis, H. macroloba, and S. ilicifolium. e overall aim of this study was to explore the potentials of these abundant species of seaweed for utilization as a functional food for human consumption, in order to promote the commercial cultivation of the species
Summary
Marine seaweed is a diverse group of marine resources that are commonly found in the maritime regions of the world. Seaweed epitomizes a lavish cradle of natural products, containing highly treasured chemicals that have not been properly investigated for their valuable compositions. Trade in macroalgae (seaweed) is a multibillion-. Evidence-Based Complementary and Alternative Medicine dollar industry [1] with world production of seaweed increasing between 1970 and 2010 from
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-based complementary and alternative medicine : eCAM
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
