Abstract
Abstract Two new erythroxylane diterpenes, named givotin A (1) and givotin B (2) were isolated from the bark of Givotia madagascariensis. Their structures have been established as 3α,12α-dihydroxy- 4(19),15-erythroxyladiene (1) and 3α-hydroxy-4(19),15-erythroxyladiene (2), respectively, on the basis of one and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, NOESY, NOE difference spectra) as well as on mass spectral analysis. In addition six known compounds (3 - 8) have been isolated and identified. Cleistanthol (3), spruceanol (4) and 1,2- dihydroheudelotinol (5) demonstrated significant antitumor activities against three tumor cell lines (HM02, Hep G2, MCF7).
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