Abstract
The chemical composition, anti-inflammatory, cytotoxic and antioxidant activities of essential oil from leaves of Mentha piperita (MEO) grown in China were investigated. Using GC-MS analysis, the chemical composition of MEO was characterized, showing that it was mainly composed of menthol, menthone and menthy acetate. MEO exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model. It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity. The results of this study may provide an experimental basis for further systematic research, rational development and clinical utilization of peppermint resources.
Highlights
Inflammation is regarded as an important baseline reaction responsible for manifestations of various chronic diseases such as cancer, septic shock, diabetes, atherosclerosis and obesity [1]
Essential oils and volatile constituents extracted form aromatic plants have been widely used as antiinflammatory, antitumor, antioxidant and antimicrobial agents for the prevention and treatment of different human diseases, such as cancer, cardiovascular diseases, bacterial and viral infections [3]
Dulbecco’s modified essential medium (DEME) and other cell-culture reagents including FBS fetal bovine serum (FBS) were obtained from GIBCO Inc, NY, USA. lipopolysaccharide (LPS), 3-(4,5dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT), 1,1-diphenyl-2picryl-hydrazyl (DPPH), Butylated hydroxytoluene (BHT) and ascorbic acid were purchased from Sigma-Aldrich
Summary
Inflammation is regarded as an important baseline reaction responsible for manifestations of various chronic diseases such as cancer, septic shock, diabetes, atherosclerosis and obesity [1]. Biological Activities of Essential Oil from Leaves of Mentha piperita inflammation is a critical component of tumor progression. Many cancers arise from sites of infection, chronic irritation and inflammation. Essential oils and volatile constituents extracted form aromatic plants have been widely used as antiinflammatory, antitumor, antioxidant and antimicrobial agents for the prevention and treatment of different human diseases, such as cancer, cardiovascular diseases (including atherosclerosis and thrombosis), bacterial and viral infections [3]. Essential oils derived from several plants have been found to have antiinflammatory, cytotoxic and antioxidant activities [4,5,6]
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