Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit.

Jayachithra Ramakrishna Pillai,Adil Farooq Wali,Tanveer A Wani,Godfred Antony Menezes,Muneeb U Rehman,Tahir Maqbool Mir,Azher Arafah,Seema Zargar

doi:10.3390/molecules27051480

Abstract

Physalis angulata L. belongs to the family Solanaceae and is distributed throughout the tropical and subtropical regions. Physalis angulata leaf and fruit extracts were assessed for in vitro anticancer, antioxidant activity, and total phenolic and flavonoid content. The GC-MS technique investigated the chemical composition and structure of bioactive chemicals reported in extracts. The anticancer activity results revealed a decrease in the percentage of anticancer cells’ viability in a concentration- and time-dependent way. We also noticed morphological alterations in the cells, which we believe are related to Physalis angulata extracts. Under light microscopy, we observed that as the concentration of ethanolic extract (fruit and leaves) treated HeLa cells increased, the number of cells began to decrease.

Highlights

Plants with medicinal properties serve as the basic treatment for many ailments in cultural diversities worldwide
The results show that Physalis angulata leaves and fruit extracts possess moderate activity on these pathogens
The present study discussed the cytotoxic activity of the ethanolic extracts of Physalis angulata leaves and fruit

Summary

Introduction

Plants with medicinal properties serve as the basic treatment for many ailments in cultural diversities worldwide. These medicinal plants exhibit various activities against many major diseases and their active constituents. Medicinal plants are the primary source of treatment for a wide range of health issues. Another reason is that herbal treatments are readily available and accessible and are very inexpensive. People in rural areas still rely on herbal medicines to treat all of their health problems. Phytomedicine is widely used in modern medicine to treat various disorders, including diabetes and cancer. According to the World Health Organization (WHO), herbal medicine is used by 60% of the world’s population, and about 80% of the people in emerging nations rely on it nearly entirely for their basic health care requirements. [1,2,3]

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