Abstract
In the rural Xuan Wei County, Yunnan Province, lung cancer mortality rates for women are among the highest in China. Most of these women are nonsmokers, and studies have shown that lung cancer in Xuan Wei is as- sociated with domestic use of smoky coal under unvented conditions. The objective of this study is to determine the chemical constituents that may be linked to the high lung cancer rates in Xuan Wei using the bioassay-directed fractionation method. Ten high-volume filter samples (<lo pm) collected from the home inhabited by a person with lung cancer during cooking periods on four consecu- tive days were subjected to Soxhlet extraction. This composite sample extract was fractionated on a normal- phase column into seven fractions. The second fraction was the most active in the bioassay, containing mainly polycyclic aromatic hydrocarbon (PAH) and alkylated PAH. The two polar fractions 6 and 7 were the next most active. The most active PAH fraction was further sepa- rated into
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