Abstract
Chemical castration by a single intratesticular injection of lactic acid, which is used for cattle, was studied in rats and dogs. The injection caused necrosis of the testicular tissue in both species. Lesions in the testes were observed as early as 24 h after the injection. Plasma testosterone levels declined rapidly after treatment and remained low thereafter. The results showed that a long-lasting and probably irreversible suppression of spermatogenesis can be brought about easily and immediately by an injection of lactic acid into the testes, and that the procedure could be used for the castration of dogs.
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