Abstract
We investigated the suggestion [R.E. Albert, Environ. Health Perspect. 105 (1997) 940–948.] that results of mutagenicity testing in Salmonella combined with allergic contact dermatitis (ACD) testing in humans would be predictive of carcinogenicity in rodents. Using the cancer bioassay results of the US National Toxicology Program (NTP), Salmonella mutagenicity tests and a highly predictive structure–activity relational model of ACD, we conclude that the combination is not more predictive than the results of the Salmonella mutagenicity assay alone.
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Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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