Abstract
Forty one-month-old hamsters were assigned to four experimental groups. All animals received an application of 0.5 per cent DMBA in liquid paraffin to the right cheek pouch, three times a week for four weeks. For one group, drinking water was supplemented with 100 ppm zinc for the duration of carcinogen painting only. The second group was supplemented only after painting and the third group received zinc throughout the experiment. The fourth (control) group did not receive zinc. Premalignant lesions arose in all but one animal and, in two-thirds of the animals, malignant change ensued. Compared with the control group, the period of latency before premalignant change was slightly extended in supplemented animals but overall there were no statistical differences between the groups. A distinct inhibitory effect of zinc in this form of carcinogenesis was not shown.
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