Abstract
Patients and methods The carcinogen DMBA was administered by gavage to 70 Balb/c female mice, diluted in corn oil, at hebdomadary doses of 1 mg per animal for 1, 3, 6 or 9 weeks. Others 20 animals were used in the control group, who received only corn oil administration. Animals were weighed and monitored weekly until death, remaining animals were euthanized at age of 53 weeks. At necropsy, representative fragments of tumors were harvested, routinely processed for microscopy and classified agreeing with International Agency for Research on Cancer (IARC).
Highlights
Experimental models of carcinogenesis have been used in cancer researches, mainly with radiation or chemicals like 7,12-dimethylbenzanthracene (DMBA) which is a polycyclic aromatic hydrocarbon
Background Experimental models of carcinogenesis have been used in cancer researches
This chemical group contains the majority of carcinogens
Summary
Experimental models of carcinogenesis have been used in cancer researches, mainly with radiation or chemicals like 7,12-dimethylbenzanthracene (DMBA) which is a polycyclic aromatic hydrocarbon.
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