Abstract
Solvent extraction separation of99mTc from99Mo using methyl ethyl ketone(MEK) has been found to be an effective method of obtaining99mTc of medicinal purity from low specific activity99Mo. The authors have investigated the effect of alkali and molybdenum concentration on the extraction of99Mo and99mTc into methyl ethyl ketone. The possibility of methyl ethyl ketone forming enol and condensation products and its effect on the final extraction efficiency and purity of99mTc has been studied. Sodium molybdate has been found to have a good salting out effect on99mTc pertechnetate and hence99mTc extraction can be better accomplished from low specific activity99Mo solutions. The ketone seems to form traces of condensation products in the extraction procedure. These have been found to be coextracted with99mTc into MEK but did not affect the extractability of99mTc. It was observed that neutral alumina column removes these condensation products from MEK containing99mTc. Alternately these could be filtered off by acidification of the final aqueous99mTc solution. The studies indicate that under optimum experimental conditions methyl ethyl ketone separates99mTc from99Mo with high efficiency and yields99mTc of high purity suitable for use in nuclear medicine in the form of various labelled compounds.
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