Abstract
WE have found immunological and chemical differences between the colonic mucoprotein antigen (CMA) isolated from normal and tumour tissue. CMA is one of at least ten antigens reported from human colonic mucosa, one or more of which has been claimed to be tissue specific. Nairn1 demonstrated histologically that one of these was a mucoprotein similar to the blood group substances, yet distinct and specific for the gastrointestinal system. Its clinical importance was emphasised by Bromberger and Perlmann2, who demonstrated the presence of antibodies to it in the sera of patients with ulcerative colities. The differences reported here may be useful as diagnostic markers for colonic carcinoma.
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