Abstract
Roots of Angelica sinensis (Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species of Angelica roots called A. gigas is being used in Korea. To reveal the efficiency of different Angelica roots, the chemical and biological properties of Angelica roots from different cultivated regions were compared. Roots of A. sinensis contained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found in A. gigas roots. The extracts deriving from A. gigas roots showed better effects in osteogenic and estrogenic properties than that of A. sinensis from China. However, this difference was markedly reduced when the Angelica roots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared from A. sinensis roots showed better responses in cell cultures. In addition, the extracts of A. gigas roots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties of Angelica roots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction.
Highlights
Angelica Sinensis Radix (ASR, the roots of Angelica sinensis; Danggui) is one of the commonly used traditional Chinese medicines (TCM), which has been used for more than 2000 years in China
In order to reveal the role of Angelica root in a herbal decoction, here, we compared osteogenic, estrogenic, and hematopoietic effects of Danggui Buxue Tang (DBT) prepared from different Angelica roots
Fresh plants were obtained from China: A. sinensis from Gansu, Yunnan, Sichuan, Jiling, Shanxi, Hunan, and Hubei were collected by ourselves; A. gigas from Republic of Korea (ROK) and Democratic People’s Republic of Korea (DPRK) were collected by Dr H
Summary
Angelica Sinensis Radix (ASR, the roots of Angelica sinensis; Danggui) is one of the commonly used traditional Chinese medicines (TCM), which has been used for more than 2000 years in China. Previous study suggested that these two commonly used Angelica roots showed variation in their chemical compositions, pharmacological properties, and clinical efficacies [8]; chemical and biological comparisons between these two Angelica roots have not been done. These problems compromise the values of TCM or even jeopardize the safety of consumers. In order to reveal the role of Angelica root in a herbal decoction, here, we compared osteogenic, estrogenic, and hematopoietic effects of DBT prepared from different Angelica roots
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