Abstract
A new carbazole alkaloid, clausine-L together with 11 known compounds, safrole, glutinol, 13 2-hydroxy(13 2- R)-pheophytin-a, methyl pheophobide-a, scopoletin, steroidal glycoside [β-sitosteryl glucoside +stigmasteryl glucoside], 2-methoxy-4-(2-propenyl)phenyl-β- d-glucoside, 2,6-dimethoxy-4-(2-propenyl)phenyl-β- d-glucoside, p-hydroxybenzoic acid, rutin and nicotiflorin were isolated and characterized from the leaves of Clausena excavata. Their structures were elucidated by spectroscopic methods and/or chemical transformation. Among them, safrole showed significant antiplatelet aggregative activity which was induced by arachidonic acid and collagen.
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