Abstract
To allow early detection and prevention of metabolic disorders, circulating levels of adipokines involved in insulin sensitivity were compared with the hyperinsulinemic-euglycemic clamp. Twenty non-obese normo-glycaemic men (age 32.1 ± 6 years) underwent a clamp procedure. Levels of leptin, adiponectin, resistin, visfatin, omentin and chemerin levels were determined in fasting blood samples. Pearson correlation coefficients between the M-value for insulin sensitivity and fasting levels of chemerin (r = −0.63, P = 0.003) and leptin (r = −0.54, P = 0.013) performed better than conventional surrogate measures of insulin sensitivity (HOMA-IR: r = −0.45, P = 0.048; Quicki: r = 0.36, P = 0.12). However, only the relation between M-valueLBM and chemerin remained significant when adjusting for BMI and fasting insulin levels (r = −0.559, P = 0.016). In conclusion, fasting levels of chemerin might be used as biomarker to identify insulin resistance in healthy men without typical characteristics of metabolic disorders.
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