Abstract
Previous work on lipid interactions has shown that zwitterionic buffers affect the attractive and repulsive forces between bilayers. The equilibrium spacing between lipid multilayers as measured by small angle x-ray scattering is determined by the balance of van der Waals (vdW), electrostatic and fluctuation forces. We will present a series of small angle x-ray scattering experiments that explores how chelating agents such as ethylenediaminetetraacetic acid (EDTA) modify the interactions between membrane. EDTA was shown to induce a phase coexistence in multilamellar systems of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) [1]. In this study we show that the effect of EDTA depends on other mobile ions in solution and lipid type. These data require a reevaluation of theoretical models of lipid bilayer interactions. [1] Johnson et al, Langmuir 2014.
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