Abstract

Sir,The article by Musk and Hergenrother demonstratingthe effectiveness of iron-saturated iron-chelators directedagainst Pseudomonas aeruginosa biofilms is intriguing andoffers therapeutic hope to individuals with cystic fibrosis(CF) whose lives are foreshortened by infection with thisiron-requiring bacterium (Musk and Hergenrother 2008).However, as the authors highlight, there is a lack ofappropriate animal models in which to test their findingsbefore potential human studies can be considered. Anadditional factor is that while the data of Musk and Her-genrother clearly show that high iron concentrations(>50 lmol l

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