Abstract

The assessment and management of tuberculous meningitis (TBM) is often complex, yet no standardised approach exists, and evidence for the clinical care of patients, including those with critical illness, is limited. The roles of proformas and checklists are increasing in medicine; proformas provide a framework for a thorough approach to patient care, whereas checklists offer a priority-based approach that may be applied to deteriorating patients in time-critical situations. We aimed to develop a comprehensive assessment proforma and an accompanying 'priorities' checklist for patients with TBM, with the overriding goal being to improve patient outcomes. The proforma outlines what should be asked, checked, or tested at initial evaluation and daily inpatient review to assist supportive clinical care for patients, with an adapted list for patients in critical care. It is accompanied by a supporting document describing why these points are relevant to TBM. Our priorities checklist offers a useful and easy reminder of important issues to review during a time-critical period of acute patient deterioration. The benefit of these documents to patient outcomes would require investigation; however, we hope they will promote standardisation of patient assessment and care, particularly of critically unwell individuals, in whom morbidity and mortality remains unacceptably high.

Highlights

  • 31 Oct 2019Any reports and responses or comments on the article can be found at the end of the article

  • Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB) and causes critical illness from direct neurological injury or complications from the infection, treatment, or prolonged hospitalisation.Due to serious complications, the management of TBM is complex, and includes supportive medical and neurosurgical measures

  • In the supporting document we have added the sentence ‘Cerebral venous thrombosis is an unusual cause of acute neurological deterioration in TBM, but has been described’ with references

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Summary

31 Oct 2019

Any reports and responses or comments on the article can be found at the end of the article. Abbreviations AFB, acid-fast bacilli; ALT, alanine transaminase; ART, antiretroviral therapy; AST, aspartate aminotransferase; BCG, Bacillus Calmette Guerin; CO , carbon dioxide; CBF, cerebral blood flow; CPP, cerebral perfusion pressure; CRP, C-reactive protein; CSF, cerebrospinal fluid; CSW, cerebral salt wasting; CT, computed tomography; CVP, central venous pressure; ESR, erythrocyte sedimentation rate; ETCO2, end-tidal carbon dioxide; ETV, endoscopic third ventriculostomy; EVD, external ventricular drainage; GCS, Glasgow coma scale; HIV, human immunodeficiency virus; ICP, intracranial pressure; ICU, intensive care unit; INR, international normalised ratio; IVC, inferior vena cava; MAP, mean arterial pressure; MRI, magnetic resonance imaging; NIRS, near-infrared spectroscopy; ONSD, optic nerve sheath diameter; PbtO2, brain tissue oxygen tension monitoring; SIADH, syndrome of inappropriate diuretic hormone secretion; TB, tuberculosis; TBI, traumatic brain injury; TBM, tuberculous meningitis; TCD, transcranial Doppler; VP, ventriculoperitoneal

Introduction
52. Rajshekhar V
66. Lang EW
77. Ropper AH
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