Abstract
Check'-ing DLBCL.
Highlights
Www.impactjournals.com/oncoscience a novel and efficient therapeutic strategy for DLBCL with Myc overexpresssion, and for other malignant B-cell lymphomas characterized by high Myc levels and high degree of genomic instability, like mantle cell lymphomas, even in cases with inactive p53
Chromosomal missegregation defects in DLBCL visualized under the microscope are much more frequent in patients with short overall survival and inferior response to therapy [5]
Occasional mutations and loss of Chk2 protein expression in aggressive lymphomas, such as mantle cell lymphomas, had been previously associated with high levels of chromosomal instability [7]. All these studies highlight the importance of the DNA damage response (DDR) pathway in aggressive lymphoma pathogenesis, but the functional consequences and their direct link with chromosomal instability have still to be elucidated
Summary
Www.impactjournals.com/oncoscience a novel and efficient therapeutic strategy for DLBCL with Myc overexpresssion, and for other malignant B-cell lymphomas characterized by high Myc levels and high degree of genomic instability, like mantle cell lymphomas, even in cases with inactive p53. Chromosomal missegregation defects in DLBCL visualized under the microscope are much more frequent in patients with short overall survival and inferior response to therapy [5]. Some concerns before including this strategy in clinical trials are the difficulties in standardizing the quantitative evaluation of MYC expression in tumors.
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