Abstract
AbstractThe testing of antibiotics for sterility is an essential stage in the manufacturing process. Before sterility testing the antibiotic must either be removed or be inactivated. The conventional methods for sterility testing of antibiotics use the technique of membrane filtration for separation of contaminating microorganisms from the inhibitory effects of antibiotics prior to cultivation. The results suggest the possibility of adsorption of antibiotic onto the filter and its subsequent release into the nutrient medium. This problem may be partially resolved by the use of a filter with hydrophobic edges. Washing with 300 ml peptone water does not generally eliminate the antibacterial activity. The filter must be washed well to ensure complete removal of the antibiotic and can also be washed with an inactivating agent if available.
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