Abstract
Human enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. Presently, no vaccines or antiviral drugs have been clinically available to employ against EV71. In this study, we demonstrate that treatment with chebulagic acid reduced the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 μg/mL. The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. Chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.
Highlights
Human enterovirus 71 (EV71) is a single-stranded positive-sense RNA virus belonging to the enterovirus genus of the Picornaviridae family [1]
The efficacy of chebulagic acid was first tested on human rhabdomyosarcoma (RD) cells infected with EV71 in a plaque reduction assay
The cytopathic effect of the RD cells caused by the viral infection was significantly inhibited after the treatment with chebulagic acid at 2 h post EV71 infection, and the viral RNA copies were clearly reduced in the infected RD
Summary
Human enterovirus 71 (EV71) is a single-stranded positive-sense RNA virus belonging to the enterovirus genus of the Picornaviridae family [1]. EV71 infection was associated with a series of clinical diseases including hand, foot, and mouth disease (HFMD). This illness can be resolved spontaneously; EV71 infections can cause severe neurological disorders that are a serious threat to children under 6 years of age [2]. Since it was first identified in 1969, outbreaks of infection due to this virus have been periodically reported worldwide, in the. We reported the antiviral effect of chebulagic acid against EV71 both in vitro and in vivo
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
