CHD3/4/5/6/8 serve as potential prognostic predictors in human gastric cancer

Abstract

Chromodomain helicase DNA (CHD) binding protein is one class of chromatin remodeling factors, which are essential in gastric cancer (GC) development. However, the role of distinct CHD family member in GC is rarely understood. To resolve this issue, a comprehensive analysis of the prognostic significance of CHD members in GC was performed using Oncomine, UALCAN, GEPIA, Kaplan–Meier Plotter, cBioPortal, LinkedOmics and STRING databases. The mRNA expression of all CHD members was different in GC samples compared with normal controls, and CHD 1/2/3/6/9 expression was remarkedly correlated with advanced cancer stage. Higher CHD3/4/6/8 expression was found significantly associated with poor overall survival (OS), post-progression survival (PPS) and progression-free survival (PFS). Conversely, higher CHD5 expression was remarkedly correlated with better OS, PPS, PFS. The study reveals that CHD3/4/5/6/8 could serve as prognostic biomarkers for GC patients. However, future researches are required to assess the clinical utility of CHD members in GC.