Abstract
The cardiac action potential (AP) is fundamental to the rate and rhythm of the normal heartbeat. We have known for a long time that various ionic currents underlie the voltage waveform. Many of these currents have been carefully studied by isolating them using various solutions and voltage clamp techniques. In the report by Banyasz et al,1 they have done the opposite, that is, by using an “onion peeling” technique, these investigators have systematically blocked various channels/transporters to understand the dynamics of a current in response to a single AP voltage profile.
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