Abstract
Charles Herbert Best was an American-Canadian biochemist and physiologist, most well known for his work in discovering insulin with Frederick Grant Banting at the University of Toronto, Canada. He and Banting worked feverishly in the summer of 1921 under J. J. R. Macleod’s supervision to isolate a pancreatic extract which would lower blood sugar in pancreatectomized diabetic dogs, later to be called insulin. When the Nobel Prize for Physiology in 1923 was awarded to Banting and Macleod and not Best, it generated immediate controversy, and over the years, it would be realized that Best may have been overlooked. Charles Best had a tremendously successful academic career at the University of Toronto not only in carbohydrate metabolism and insulin but he also made several other contributions with important work in choline, histaminase, and heparin.
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