Abstract
Sulpiride is a drug used in therapy for schizophrenia. This drug’s capacity to generate charge-transfer (CT) complexes was investigated and discussed. Its reaction with five different acceptor molecules: tetrafluoro-1,4-benzoquinone (TFQ), chloranilic acid (CLA), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), 7,7,8,8-tetracyanoquinodimethane (TCNQ), and iodine crystals (I2). These CT complexation reactions generated stable CT complexes at ratios of 1:2 with I2 and 1:1 with the other acceptors independent of the state (liquid or solid) of the starting materials. Pronounced color changes were observed upon mixing the sulpiride donor with each acceptor in both liquid and solid forms. Using Fourier-transform infrared spectroscopy, UV–Vis spectroscopy, and CHNS elemental measurements, the chemical structure and mechanism of interaction were characterized to assess the synthesized CT complexes.
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