Abstract
Objective: Oxidative stress which comes from hyperglycemia, it accelerates the development of cellular and vascular damage complications in diabetes, but the antioxidants may play a beneficial role in its prevention. Several plants extracts have an antioxidant activity and the ability to reduce oxidative stress in diabetes. Thus this study was conducted to investigate the effect of Beta vulgaris var cicla extract on zinc status, glucose concentration and antioxidant parameters in streptozotocin-diabetic rats fed zinc deficiency diet.Methods: Twenty-eight male albino (Wistar) rats were divided into four groups: two groups fed a zinc-sufficient diet one non-diabetic and the other diabetic, while the others two diabetic groups were fed a zinc-deficient diet, one non-treated group and the other treated with the extract of Beta vulgaris var cicla. After 21 d of dietary manipulation, fasting animals were scarified. Blood glucose, tissues zinc (femur, liver, kidney), malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) were evaluated.Results: Body weight gain of zinc-deficient diabetic animals was lower than that of zinc-adequate diabetic animals. It was noticed also that inadequate dietary zinc intake increased glucose and MDA levels. In addition, zinc deficiency diet led to a decrease in zinc tissues, GSH concentration both GST and GSH-Px activities. However, Oral administration of Beta vulgaris extract significantly decreased both serum glucose and MDA (p<0.001) levels, with a significant increase in body weight gain (p<0.001), GSH concentration (p<0.05, P<0.001), GST (p<0.05, p<0.001) and GSH-Px (p<0.001) activities.Conclusion: The present study showed that Beta vulgaris var cicla supplementation presumably acting as an antioxidant, and it can be a natural source for the reduction of diabetes development caused by zinc deficiency.
Highlights
Diabetes mellitus is a hereditary, chronic disorder in the endocrine system that constitutes a major public health problem throughout the world [1]
The present investigation was aimed at evaluating the modulator effects of Beta vulgaris var cicla administration for prevention the development of diabetic pathology observed in zinc deficiency by evaluating body weight gain, zinc status, glucose level and antioxidant system in streptozotocine diabetic rats
Antioxidant compounds like phenolic acids, polyphenols and flavonoids scavenge free radicals such as peroxide, hydroperoxide of lipid hydroxyl and halt the oxidative mechanism that leads to degenerative diseases [29]
Summary
Diabetes mellitus is a hereditary, chronic disorder in the endocrine system that constitutes a major public health problem throughout the world [1]. Zinc is an essential component of numerous proteins, which play crucial roles in growth and development It showed potent antioxidant and anti-inflammatory properties and was involved in the defence against oxidative stress [8]. Zinc has been reported to exert antidiabetic effects in various experimental models [10] It seems that zinc deficiency increases the risk for several chronic disease states such as diabetes [11], and this risk may be associated with an increased vulnerability to oxidative stress [12]. The present investigation was aimed at evaluating the modulator effects of Beta vulgaris var cicla (chard) administration for prevention the development of diabetic pathology observed in zinc deficiency by evaluating body weight gain, zinc status, glucose level and antioxidant system in streptozotocine diabetic rats
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