Abstract
Characterizing the transient K+current contribution to subthreshold membrane potential oscillations in a hippocampal interneuron model
Highlights
A class of hippocampal interneurons in the CA1 region, bordering the lacunosum moleculare and radiatum hippocampal layers, has been shown to exhibit membrane potential oscillations (MPOs) subthreshold to action potential generation [1,2]
MPOs can be generated in the absence of synaptic input suggesting that they originate through interactions in the cell's repertoire of currents
In this study we present a model of the LM/R cell and show that IA can enhance MPOs through modulation of the action potential threshold
Summary
A class of hippocampal interneurons in the CA1 region, bordering the lacunosum moleculare and radiatum hippocampal layers (the LM/R cell), has been shown to exhibit membrane potential oscillations (MPOs) subthreshold to action potential generation [1,2]. Published: 11 July 2008 BMC Neuroscience 2008, 9(Suppl 1):O7 doi:10.1186/1471-2202-9-S1-O7 These oscillations occur at theta frequency (4–12 Hz) and are of interest because of their putative role in promoting theta activity at the network level.
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