Abstract
Genome-wide SNP analyses reveal the admixed African genetic ancestry of African Americans.
Highlights
IntroductionHigh-throughput genotyping allows the fine characterization of genetic ancestry
Accurate, high-throughput genotyping allows the fine characterization of genetic ancestry
We sought to characterize the African ancestry of African Americans by using data on more than 450,000 single-nucleotide polymorphism (SNP) genotyped in 94 Africans of diverse geographic origins, as well as 136 African Americans and 38 U.S Caucasians
Summary
High-throughput genotyping allows the fine characterization of genetic ancestry. Numerous studies have estimated the rate of European admixture in African Americans; these studies have documented average admixture rates in the range of 10% to 20%, with some regional variation, and with substantial variation among individuals [1]. Studies have focused primarily on the matrilineally inherited mitochondrial DNA (mtDNA) and patrilineally inherited Y chromosome [5,6,7] These two DNA sources have gained wide prominence owing, in part, to their use by ancestry-testing companies to identify the regional and ethnic origins of their subscribers. These two sources provide a very narrow perspective in delineating only two of possibly thousands of ancestral lineages in an individual
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