Abstract
The proper packaging of DNA in sperm is absolutely necessary for human reproduction. Sperm nuclear DNA is tightly condensed, ensuring that the sperm is hydrodynamic and compact. This process is achieved using the sperm nuclear protein protamine, which directly or indirectly replaces the histones in somatic progenitor cells during spermiogenesis. Malfunctions of the histone replacement process are a known cause of male infertility. Our goal is twofold. We will examine partial histone wrapping states, which may play a key role in the histone replacement pathway.
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