Abstract
The conservation of base sequence integrity within genomic DNA is critical to maintaining well-regulated gene expression and replication. However, the structure of DNA within the cell must be dynamic, allowing for thermally induced fluctuations (i.e. DNA ‘breathing') to facilitate productive interactions including binding-site recognition and the assembly of functional protein-DNA complexes. For example, at single-stranded (ss) – double-stranded (ds) DNA fork junctions, transient local conformational fluctuations of the sugar-phosphate backbones are likely transition states for the formation of a stable helicase-primase sub-assembly during DNA replication, with the existence of multiple DNA conformers working to facilitate competition between different protein regulatory factors and replisome proteins.
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