Abstract
Recent developments in size exclusion high performance liquid chromatography with on-line static light scattering (LS), refractive index (RI), and ultraviolet (UV) detection allow rapid solution-state characterization of glycoproteins and protein-polymer conjugates. Through simple mathematical relationships of peak areas from LS, RI, and UV detectors, the molecular mass, degree of glycosylation or polymer conjugation, and the solution association state can be readily determined. Baseline resolution of the chromatographic peaks is not required; peaks need only be sufficiently separated to represent relatively pure fractions.
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