Abstract
Cultures of primary HSCs and hematopoietic cell lines are often characterized by heterogeneous proliferation rates, a non-negligible level of background differentiation and cell death and the maintenance of self-renewal ability within a small subpopulation of cells only. The multipotent murine progenitor cell line FDCP-Mix demonstrates these features during continuous passaging in high IL-3. The mechanisms by which a small fraction of self-renewing cells is maintained in a continuously expanding, intrinsically heterogeneous population are unknown, but are likely to be relevant to similar homeostatic processes in vivo.
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