Characterizing benign breast disease in women at high risk for breast cancer.

Abstract

1506 Background: Benign breast disease (BBD) is an established risk factor for breast cancer, with the highest risk associated with atypical proliferative subtypes. In the general population, atypical hyperplasia (AH) is associated with a 20-50% increase in invasive breast cancer risk persisting at least 25 years post biopsy. Limited information exists on the prevalence and characteristics of BBD in women at high risk for breast cancer. Methods: In an ongoing prospective study of women with a family history of breast cancer and/or a BRCA1/2 mutation who attend the Breast and Ovarian Surveillance Service (BOSS) at Johns Hopkins (n = 953), we identified 575 women who reported having at least one breast surgical procedure at the time of enrollment. 66% of these women had 2 or more relatives with breast and/or ovarian cancer. 257 breast cancer cases and 170 cases of incident BBD were subsequently confirmed based on pathology report. Slides were then obtained for re-review and evaluation of specific histologic...