Abstract
The tectorial membrane (TM) is an important structural component of the mammalian inner ear. Examination of cochlear physiology in genetically modified mice has demonstrated that mutation of genes affecting TM proteins causes changes in key characteristics of cochlear function. Characterizing the differences in material properties between wild-type and mutant mice could provide insight into the source of reported differences in cochlear physiology. In this study, optical images of isolated TM segments of wild-type and genetically modified mice in response to harmonic radial excitation at acoustic frequencies are used to determine the amplitude and phase of the motion. Wave propagation on the TM segments is modeled using finite element models that take into account the anisotropy, viscoelasticity, and finite dimensions of the TM and the presence of a viscous boundary layer. An automated least-square fitting algorithm is used to find anisotropic, viscoelastic material parameters of wild-type and mutant mice TMs at acoustic frequencies. The resulting material properties are compared to previous estimates of the TM properties.The tectorial membrane (TM) is an important structural component of the mammalian inner ear. Examination of cochlear physiology in genetically modified mice has demonstrated that mutation of genes affecting TM proteins causes changes in key characteristics of cochlear function. Characterizing the differences in material properties between wild-type and mutant mice could provide insight into the source of reported differences in cochlear physiology. In this study, optical images of isolated TM segments of wild-type and genetically modified mice in response to harmonic radial excitation at acoustic frequencies are used to determine the amplitude and phase of the motion. Wave propagation on the TM segments is modeled using finite element models that take into account the anisotropy, viscoelasticity, and finite dimensions of the TM and the presence of a viscous boundary layer. An automated least-square fitting algorithm is used to find anisotropic, viscoelastic material parameters of wild-type and mutant mice...
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