Abstract
Marine bioactive peptides, as a source of unique bioactive compounds, are the focus of current research. They exert various biological roles, some of the most crucial of which are antioxidant activity, antimicrobial activity, anticancer activity, antihypertensive activity, anti-inflammatory activity, and so forth, and specific characteristics of the bioactivities are described. This review also describes various manufacturing techniques for marine bioactive peptides using organic synthesis, microwave assisted extraction, chemical hydrolysis, and enzymes hydrolysis. Finally, purification of marine bioactive peptides is described, including gel or size exclusion chromatography, ion-exchange column chromatography, and reversed-phase high-performance liquid chromatography, which are aimed at finding a fast, simple, and effective method to obtain the target peptides.
Highlights
The oceans occupy more than 70% of the earth and are a rich natural resource for many bioactive compounds in organisms such as fish, shellfish, molluscs, univalves, cephalopods, crustaceans, and echinoderms, which significantly contribute to economic and research development [1, 2]
Hsu et al [49] have investigated the antiproliferative activities of peptides from Tuna Dark (Thunnus tonggol) muscle byproduct, and the results showed that the peptide fraction with the molecular weight range from 390 to 1400 Da possessed the greatest antiproliferative activity
Large numbers of bioactive peptides have been isolated from marine organisms and display strong antioxidant, antihypertension, antimicrobial, anticoagulant and antidiabetic activities, and so forth
Summary
The oceans occupy more than 70% of the earth and are a rich natural resource for many bioactive compounds in organisms such as fish, shellfish, molluscs, univalves, cephalopods, crustaceans, and echinoderms, which significantly contribute to economic and research development [1, 2]. The marine organisms have special structures and constitute nearly half of the worldwide biodiversity, like antioxidant activity, antimicrobial activity, anticancer activity, antihypertensive activity, anti-inflammatory activity, and so forth [3]. Bioactive peptides often have 3 to 20 amino acid residues, and their biological activities are based on their amino acid composition and sequence [4]. Much attention has been paid to unravelling the structural, compositional, and sequential properties of bioactive peptides [3]. This review highlights the characteristics of marine peptides with biological activities as well as the preparation and purification of such peptides
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