Abstract
ABSTRACTA key issue in using Polydimethylsiloxane (PDMS) based micropillars as cellular force transducers is obtaining an accurate characterization of mechanical properties. The Young’s modulus of PDMS has been extended from a constant in the ideal elastic case to a time-dependent function in the viscoelastic case. However, the frequency domain information is of more practical interest in interpreting the complex cell contraction behavior. In this paper, we reevaluated the Young’s relaxation modulus in the time domain by using more robust fitting algorithms than previous reports, and investigated the storage and loss moduli in the frequency domain using the Fourier transform technique. With the use of the frequency domain modulus and the deflection of micropillars in the Fourier series, the force calculation can be much simplified by converting a convolution in the time domain to a multiplication in the frequency domain.
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