Abstract
Bax inhibitor‐1 (BXI1) is an anti apoptotic gene whose human homolog's expression is upregulated in a wide range of human cancers. Studies have shown that Bxi1p is localized in the endoplasmic reticulum and is involved in the unfolded protein response (UPR) that is triggered by endoplasmic reticulum (ER) stress. BXI1 is thought to act via a mechanism involving altered calcium dynamics. In this poster, we provide evidence that suggests that the Saccharomyces cerevisiae protein facilitates Ire1p clustering in response to ER stress and alters calcium signaling. With DTT induction experiments using Δbxi1 mutants and different UPR GFP reporters, we have confirmed our published data that suggests that BXI1 is involved in the UPR, Intriguingly, our preliminary data suggests that Bxi1p facilitates clustering of Ire1p during ER stress. [Our laboratory is supported by grant NIGMS R15 GM110578, awarded to N. Austriaco.]
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