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Abstract
Herpesvirus US2 gene has different names in different subfamily herpesvirus, as does its function. Recently, we found the main function of US2 gene in herpesvirus is to target the heavy chain of major histocompatibility complex (MHC) in endoplasmic reticulum and then to induce the degradation of MHC by the proteasome in cytoplasm. MHC plays an important role in antigen presentation, but after the US2 gene interfers with the expression of MHC on cell surface, the virus can avoid the immunologic mechanism of the host because it disrupts the antigen presentation. We hope to describe the characteristics and function of the herpesvirus US2 gene and its encoding protein, and also the interactions with Us11 and Us10 proteins to enable further research on the herpesvirus genome.
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